Potentiation of antifungal effect of amphotericin B by squalene, an intermediate for sterol biosynthesis.
نویسندگان
چکیده
The antifungal effect of a polyene antibiotic amphotericin B (AMB) was almost completely abrogated by exogenous addition of 0.1 microgram/ml ergosterol in the medium. The cytocidal effect of AMB on Saccharomyces cerevisiae was synergistically enhanced when cultured for more than 4 hours with squalene, an obligatory intermediate molecule for sterol formation. However, we could not find significant increase in cellular level of ergosterol content in the yeast cells fed with squalene.
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ورودعنوان ژورنال:
- The Journal of antibiotics
دوره 35 2 شماره
صفحات -
تاریخ انتشار 1982